Basic Information

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0005
Trial ID NCT00012207
Disease Lymphoma
Altered gene CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD20 CAR-T cells
HLAMHC-independent
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Study To Evaluate The Safety Of Cellular Immunotherapy Using Genetically Modified Autologous Cd20-Specific Cd8+ T Cell Clones For Patients With Relapsed Cd20+ Indolent Lymphomas
Year2001
CountryUnited States
Company sponsorFred Hutchinson Cancer Center
Vector information
Vectorelectroporation

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.1~3.3E9 T cells
Donor type autologous
Pts 7
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 2/7(CR); 1/7(PR); 4/7(SD)
Adverse reactions no TCR related AEs
References PMID: 18509084

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