Basic Information

Gene symbol tk

GTO ID GTC0003
Trial ID NCT00005025
Disease Ovarian Cancer
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment rv.HSV-TK
PhasePhase2
Recruitment statusUnknown
TitleA Phase II Trial of In Vivo Gene Therapy With the Herpes Simplex Thymidine Kinase for the Treatment of Ovarian Cancer
Year2000
CountryUnited States
Company sponsorJohn Stoddard Cancer Center at Iowa Methodist Medical Center
Other ID(s)CDR0000067546|HGTRI-0105|NCI-V00-1584
Vector information
Vectorretrovirus

Clinical Result

Cohort 1
Administration route intratumoral injection
Pts 12
Age Adult, Older_Adult
Outcome 2/12(PR); 2/12(PD); 4/12(MR); 4/12(SD). The 6- and 12-month progression-free survival rates were 47 and 14%, respectively. The 6- and 12-month overall survival rates were 58 and 25%, respectively.
Adverse reactions only minor adverse events
References PMID: 15891772

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