Basic Information

Drug ID DDPD15685 ...
Drug Name Selpercatinib
Molecular Weight 525.613
Molecular Formula C29H31N7O3
CAS Number 2152628-33-4
SMILES COC1=NC=C(CN2C3CC2CN(C3)C2=CC=C(C=N2)C2=CC(OCC(C)(C)O)=CN3N=CC(C#N)=C23)C=C1
External Links
DRUGBANK DB15685

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Water Solubility 1000.0 mg/L <1 mg/ml https://www.selleckchem.com/msds/MSDS_S8781.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 51600.0 null 51600.0 null tumor; DRUGBANK
Bioavailability 73.0 % 73(60-82) % tumor; DRUGBANK
C Max 2980.0 null 2980.0 null tumor; DRUGBANK
T Max 2.0 h 2 h tumor; DRUGBANK
Tss 168.0 h 7.0 day tumor; DRUGBANK
Clearance 6.0 L/h 6.0 L/h apparent clearance; gaining weight ↑ ; DRUGBANK
Volume of Distribution 191.0 L 191.0 L Apparent volume of distribution; gaining weight ↑ ; DRUGBANK
Half-life 32.0 h 32 h normal,healthy; DRUGBANK
Eliminate Route 69.0 % 69 % Faeces excretion; Single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 24.0 % 24 % Urinary excretion; Single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 9.6 % 9.6 % Faeces excretion; Single dose; normal,healthy; human, homo sapiens; Unchanged drug; DRUGBANK
Eliminate Route 2.9 % 2.88 % Urinary excretion; Single dose; normal,healthy; human, homo sapiens; Unchanged drug; DRUGBANK
Protein Binding 97.0 % 97 % high protein binding; Plasma Concentration → ; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1