Basic Information
| Drug ID | DDPD15102 |
|
| Drug Name | Pemigatinib | |
| Molecular Weight | 487.508 | |
| Molecular Formula | C24H27F2N5O4 | |
| CAS Number | 1513857-77-6 | |
| SMILES | CCN1C(=O)N(CC2=CN=C3NC(CN4CCOCC4)=CC3=C12)C1=C(F)C(OC)=CC(OC)=C1F | |
| External Links | ||
| DRUGBANK | DB15102 | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 1277271.0 | ng.h | 2620.0 | nM.h | Oral multiple dose; | DRUGBANK |
| C Max | 115.1 | ng/ml | 236.0 | nM | Oral multiple dose; | DRUGBANK |
| T Max | 1.1 | h | 1.13(0.5-6) | h | Oral single dose; | DRUGBANK |
| Tss | 96.0 | h | 4.0 | day | Oral multiple dose; | DRUGBANK |
| Clearance | 10.6 | L/h | 10.6 | L/h | apparent clearance; Oral single dose; | DRUGBANK |
| Volume of Distribution | 235.0 | L | 235.0 | L | Apparent volume of distribution; Oral single dose; | DRUGBANK |
| Half-life | 15.4 | h | 15.4 | h | elimination half-life; Oral single dose; | DRUGBANK |
| Eliminate Route | 82.4 | % | 82.4 | % | Faeces excretion; Oral single dose; | DRUGBANK | Eliminate Route | 12.6 | % | ~12.6 | % | Urinary excretion; Oral single dose; | DRUGBANK | Eliminate Route | 1.2 | % | ~1.15 | % | Faeces excretion; Oral single dose; Unchanged drug; | DRUGBANK | Eliminate Route | 0.13 | % | ~0.126 | % | Urinary excretion; Oral single dose; Unchanged drug; | DRUGBANK |
| Protein Binding | 90.6 | % | 90.6 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1