| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Reference |
| T Max |
3.0 |
h |
2-4 |
h |
PO, oral; |
DRUGBANK |
| Tss |
96.0 |
h |
4.0 |
day |
Oral multiple dose; |
DRUGBANK |
| Metabolic |
79.0 |
% |
79 |
% |
Unchanged drug; |
DRUGBANK |
Metabolic |
13.0 |
% |
13 |
% |
|
DRUGBANK |
| Clearance |
53.7 |
L/h |
53.7 |
L/h |
apparent clearance; PO, oral; normal,healthy; |
DRUGBANK |
| Volume of Distribution |
224.0 |
L |
224.0 |
L |
PO, oral; rheumatoid arthritis; patients; |
DRUGBANK |
Volume of Distribution |
294.0 |
L |
294.0 |
L |
Steady state volume of distribution; normal,healthy; |
DRUGBANK |
| Half-life |
11.0 |
h |
8-14 |
h |
elimination half-life; extended release formulation; |
DRUGBANK |
| Toxicity LD50 |
14500.0 |
mg/kg |
14500.0 |
mg/kg |
PO, oral; Rattus, Rat; |
DRUGBANK |
| Eliminate Route |
53.0 |
% |
~53 |
% |
Faeces excretion; Single dose; |
DRUGBANK |
Eliminate Route |
43.0 |
% |
~43 |
% |
Urinary excretion; Single dose; |
DRUGBANK |
Eliminate Route |
20.1 |
% |
~20.14 |
% |
Faeces excretion; Single dose; Unchanged drug; |
DRUGBANK |
Eliminate Route |
10.3 |
% |
~10.32 |
% |
Urinary excretion; Single dose; Unchanged drug; |
DRUGBANK |
| Protein Binding |
52.0 |
% |
52 |
% |
plasma proteins; human, homo sapiens; |
DRUGBANK |
