Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.74 | - | 0.74 | - | https://www.tecfidera.com/content/dam/commercial/tecfidera/pat/en_us/pdf/full-prescribing-info.pdf |
| Boiling Point | 192.5 | ℃ | 192-193 | ℃ | https://www.nwmissouri.edu/naturalsciences/sds/d/Dimethyl%20fumarate.pdf |
| Melting Point | 104.0 | ℃ | 102-106 | ℃ | https://www.nwmissouri.edu/naturalsciences/sds/d/Dimethyl%20fumarate.pdf |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 1466.7 | ng.h/ml | 88.0 | mg.min/L | PO, oral; multiple sclerosis; Active metabolite; | DRUGBANK |
| C Max | 2110.0 | ng/ml | 2.11 | mg/L | PO, oral; | DRUGBANK |
| Css | 8320.0 | ng.h/ml | 8.32 | mg.h/L | PO, oral; multiple sclerosis; Active metabolite; | DRUGBANK |
| T Max | 2.8 | h | 2.5-3 | h | PO, oral; | DRUGBANK |
| Clearance | 1.5 | mg/L | 1.54 | mg/L | Average clearance; PO, oral; | DRUGBANK |
| Volume of Distribution | 77.5 | L | 72-83 | L | Apparent volume of distribution; | DRUGBANK |
| Half-life | 1.0 | h | 1 | h | terminal half-life; Active metabolite; | DRUGBANK |
| Toxicity LD50 | 2240.0 | mg/kg | 2240.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 924.0 | mg/day | 924 | mg/day | PO, oral | Vumerity | diroximel fumarate | PDR |
| Max dose for geriatric | 924.0 | mg/day | 924 | mg/day | PO, oral | Vumerity | diroximel fumarate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1