DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD14723
Drug Name	Larotrectinib
Molecular Weight	428.444
Molecular Formula	C21H22F2N6O2
CAS Number	1223403-58-4
SMILES	O[C@H]1CCN(C1)C(=O)NC1=C2N=C(C=CN2N=C1)N1CCC[C@@H]1C1=C(F)C=CC(F)=C1
External Links
	DRUGBANK	DB14723
	PDR	24274

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	4351.0	ng.h/ml	4351.0	ng.h/ml	Capsule, PO, Oral; adults;		DRUGBANK
Bioavailability	34.0	%	34(32-37）	%	Capsule, PO, Oral;		DRUGBANK
C Max	788.0	ng/ml	788.0	ng/ml	Capsule, PO, Oral; adults;		DRUGBANK
T Max	1.0	h	1	h	Capsule, PO, Oral; adults;		DRUGBANK
Tss	72.0	h	3.0	day	Capsule, PO, Oral; adults;		DRUGBANK
Clearance	98.0	L/h	98.0	L/h	Average clearance;		DRUGBANK
Volume of Distribution	48.0	L	48.0	L	Average volume of distribution; intravenous injection, IV; normal,healthy;		DRUGBANK
Half-life	2.9	h	2.9	h			DRUGBANK
Eliminate Route	58.0	%	58	%	Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens;		DRUGBANK
Eliminate Route	39.0	%	39	%	Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens;		DRUGBANK
Eliminate Route	2.9	%	2.9	%	Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens; Unchanged drug;		DRUGBANK
Eliminate Route	7.8	%	7.8	%	Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens; Unchanged drug;		DRUGBANK
Protein Binding	70.0	%	~70	%	plasma proteins; human, homo sapiens;	Plasma Concentration → ;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Frequency	Brand Name	Component	Reference
Max dose for infants	100.0	mg/m2	100	mg/m2	PO, oral	q2d	Vitrakvi	larotrectinib	PDR
Max dose for children	100.0	mg	100	mg	PO, oral	bid	Vitrakvi	larotrectinib	PDR
Max dose for children	100.0	mg/m2	100	mg/m2	PO, oral	bid	Vitrakvi	larotrectinib	PDR
Max dose for adolescents	100.0	mg	100	mg	PO, oral	bid	Vitrakvi	larotrectinib	PDR
Max dose for adults	100.0	mg	100	mg	PO, oral	bid	Vitrakvi	larotrectinib	PDR
Max dose for geriatric	100.0	mg	100	mg	PO, oral	bid	Vitrakvi	larotrectinib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1