Basic Information
| Drug ID | DDPD14596 |
|
| Drug Name | Loteprednol etabonate | |
| Molecular Weight | 466.96 | |
| Molecular Formula | C24H31ClO7 | |
| CAS Number | 82034-46-6 | |
| SMILES | [H][C@@]12CC[C@](OC(=O)OCC)(C(=O)OCCl)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C | |
| External Links | ||
| DRUGBANK | DB14596 | |
| PubChem Compound | 9865442 | |
| PDR | 24239 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.4 | - | 3.4 | - | DRUGBANK |
| Melting Point | 222.0 | ℃ | 220-224 | ℃ | DRUGBANK |
| Water Solubility | 5000.0 | mg/L | 5 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.000210 | L/h/kg | 0.21±0.04 | ml/h/kg | Renal clearance; | DRUGBANK | Clearance | 0.002410 | L/h/kg | 2.41±0.13 | ml/h/kg | Plasma clearance; | DRUGBANK |
| Volume of Distribution | 3.7 | L/kg | 3.7 | L/kg | dog; | DRUGBANK |
| Half-life | 2.8 | h | 2.8 | h | terminal half-life; dog; intravenous injection, IV; | DRUGBANK |
| Protein Binding | 98.0 | % | ~98 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 24.0 | drop/day | 24 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for adults | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for adults | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for adults | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for geriatric | 24.0 | drop/day | 24 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for geriatric | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for geriatric | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
| Max dose for geriatric | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Inveltys | loteprednol etabonate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1