Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD14569 ...
Drug Name Tedizolid
Molecular Weight 370.344
Molecular Formula C17H15FN6O3
CAS Number 856866-72-3
SMILES CN1N=NC(=N1)C1=NC=C(C=C1)C1=C(F)C=C(C=C1)N1C[C@H](CO)OC1=O
External Links
DRUGBANK DB14569

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 256.8 ℃ 256.8 ℃ https://pdf.hres.ca/dpd_pm/00032313.PDF
Water Solubility 100.0 mg/L 0.1 mg/ml https://pdf.hres.ca/dpd_pm/00032313.PDF
pKa 4.15 - 1.8,6.5 - https://pdf.hres.ca/dpd_pm/00032313.PDF

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 23800.0 ng.h/ml 23.8±6.8 mcg.h/ml PO, oral; DRUGBANK
AUC 26600.0 ng.h/ml 26.6±5.2 mcg.h/ml intravenous injection, IV; DRUGBANK
Bioavailability 91.0 % ~91 % PO, oral; DRUGBANK
C Max 2000.0 ng/ml 2.0±0.7 mcg/ml PO, oral; DRUGBANK
C Max 3000.0 ng/ml 3.0±0.7 mcg/ml intravenous injection, IV; DRUGBANK
Css 2200.0 ng/ml 2.2±0.6 mcg/ml PO, oral; DRUGBANK
Css 2300.0 ng/ml 2.3±0.6 mcg/ml intravenous injection, IV; DRUGBANK
T Max 3.0 h 3 h PO, oral; DRUGBANK
T Max 2.5 h 2.5(1.0-8.0) h PO, oral; DRUGBANK
T Max 1.2 h 1.2(0.9-1.5) h intravenous injection, IV; DRUGBANK
Tss 72.0 h 3.0 day PO, oral; DRUGBANK
Tss 72.0 h 3.0 day intravenous injection, IV; DRUGBANK
Tss 3.5 h 3.5(1.0-6.0) h PO, oral; DRUGBANK
Tss 1.1 h 1.1(0.9-1.5) h intravenous injection, IV; DRUGBANK
Clearance 6.9 L/h 6.9±1.7 L/h apparent clearance; Oral single dose; DRUGBANK
Clearance 8.4 L/h 8.4±2.1 L/h apparent clearance; at steady state; DRUGBANK
Clearance 6.4 L/h 6.4±1.2 L/h Total clearance; Oral single dose; DRUGBANK
Clearance 5.9 L/h 5.9±1.4 L/h Total clearance; at steady state; DRUGBANK
Clearance 0.0714 L/h/kg 1.19 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 73.5 L 67-80 L intravenous injection, IV; Single dose; DRUGBANK
Volume of Distribution 108.0 L 108 ± 21 L PO, oral; DRUGBANK
Volume of Distribution 113.3 L 113.3 ± 19.3 L Apparent volume of distribution; Oral single dose; DRUGBANK
Volume of Distribution 0.91 L/kg 0.91 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 12.0 h ~12 h DRUGBANK
Half-life 10.2 h 10.16 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 82.0 % ~82 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 18.0 % ~18 % Urinary excretion; Oral single dose; DRUGBANK
Protein Binding 80.0 % ~70-90 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1