Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD14512 ...
Drug Name Mometasone furoate
Molecular Weight 521.429
Molecular Formula C27H30Cl2O6
CAS Number 83919-23-7
SMILES [H][C@@]12C[C@@H](C)[C@](OC(=O)C3=CC=CO3)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
External Links
DRUGBANK DB14512
PDR 24091

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.115 - 4.115 - DRUGBANK
Melting Point 221.5 ℃ 215-228 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 1.0 % <1 % inhalation, IH; DRUGBANK
Bioavailability 11.0 % 11.0 % different study; increasing dosing frequency ↑ ; DRUGBANK
Bioavailability 0.70 % 0.7 % ointment; DRUGBANK
T Max 1.8 h 1.0-2.5 h inhalation, IH; DRUGBANK
Clearance 90.0 L/h ~90 L/h DRUGBANK
Clearance 0.76 L/h/kg 12.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 152.0 L 152.0 L Steady state volume of distribution; DRUGBANK
Volume of Distribution 2.2 L/kg 2.2 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.0 h ~5 h terminal half-life; DRUGBANK
Half-life 5.8 h 5.8 h different study; DRUGBANK
Half-life 4.4 h 4.4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 74.0 % ~74 % Faeces excretion; DRUGBANK
Eliminate Route 8.0 % ~8 % Urinary excretion; DRUGBANK
Protein Binding 98.5 % 98-99 % high protein binding; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 1.0 appLication/day 1 appLication/day skin ointment Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.2 mg/day 200 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.88 mg/day 880 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.8 mg/day 800 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 1.0 appLication/day 1 appLication/day skin ointment Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.1 mg/day 100 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.11 mg/day 110 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.2 mg/day 200 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 1.0 appLication/day 1 appLication/day skin ointment Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.1 mg/day 100 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.11 mg/day 110 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 1.0 appLication/day 1 appLication/day skin ointment Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for infants 0.1 mg/day 100 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for children 1.0 application/day 1 application/day skin ointment Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for children 0.2 mg/day 200 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for children 0.88 mg/day 880 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for children 0.8 mg/day 800 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for adolescents 0.4 mg/day 400 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for adolescents 0.88 mg/day 880 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for adolescents 0.8 mg/day 800 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for geriatric 0.4 mg/day 400 mcg/day nasal spray Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for geriatric 0.88 mg/day 880 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR
Max dose for geriatric 0.8 mg/day 800 mcg/day inhalation, IH Mometasone Furoate Topical Solution mometasone furoate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1