DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD13997
Drug Name	Baloxavir marboxil
Molecular Weight	571.55
Molecular Formula	C27H23F2N3O7S
CAS Number	1985606-14-1
SMILES	[H][C@@]12COCCN1C(=O)C1=C(OCOC(=O)OC)C(=O)C=CN1N2[C@H]1C2=CC=C(F)C(F)=C2CSC2=CC=CC=C12
External Links
	DRUGBANK	DB13997
	PDR	24258

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	2.24	-	2.24	-	MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
T Max	4.0	h	4	h		DRUGBANK
Clearance	10.3	L/h	10.3	L/h		DRUGBANK
Volume of Distribution	1180.0	L	1180.0	L	Apparent volume of distribution;	DRUGBANK
Half-life	79.1	h	79.1	h	elimination half-life;	DRUGBANK
Toxicity LD50	2000.0	mg/kg	>2000	mg/kg	PO, oral; Rattus, Rat;	DRUGBANK
Eliminate Route	14.7	%	14.7	%	Urinary excretion; Single dose;	DRUGBANK
Eliminate Route	80.1	%	80.1	%	Faeces excretion; Single dose;	DRUGBANK
Protein Binding	93.4	%	92.9-93.9	%		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for children	80.0	mg	80	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for children	40.0	mg	40	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for adolescents	80.0	mg	80	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for adolescents	40.0	mg	40	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for adults	80.0	mg	80	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for adults	40.0	mg	40	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for geriatric	80.0	mg	80	mg	PO, oral	Xofluza	baloxavir marboxil	PDR
Max dose for geriatric	40.0	mg	40	mg	PO, oral	Xofluza	baloxavir marboxil	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1