Basic Information
| Drug ID | DDPD13867 |
|
| Drug Name | Fluticasone | |
| Molecular Weight | 444.51 | |
| Molecular Formula | C22H27F3O4S | |
| CAS Number | 90566-53-3 | |
| SMILES | [H][C@@]12C[C@@H](C)[C@](O)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C | |
| External Links | ||
| DRUGBANK | DB13867 | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 0.0500 | % | 0.05 | % | intranasal; Drug form; | DRUGBANK | Bioavailability | 1.3 | % | 1.26 | % | PO, oral; Drug form; | DRUGBANK | Bioavailability | 13.9 | % | 13.9 | % | inhalation, IH; Drug form; | DRUGBANK | Bioavailability | 12.4 | % | 6.3-18.4 | % | inhalation, IH; Drug form; Male, men; Caucasian; | DRUGBANK | Bioavailability | 2.0 | % | <2 | % | intranasal; Drug form; | DRUGBANK | Bioavailability | 1.0 | % | <1 | % | PO, oral; Drug form; | DRUGBANK | Bioavailability | 9.0 | % | 9 | % | inhalation, IH; Drug form; Male, men; Caucasian; | DRUGBANK |
| Clearance | 57.8 | L/h | 57.8 | L/h | DRUGBANK | Clearance | 71.8 | L/h | 71.8 | L/h | intravenous injection, IV; normal,healthy; Caucasian; Male, men; | DRUGBANK | Clearance | 65.6 | L/h | 1093.0 | ml/min | DRUGBANK | Clearance | 63.9 | L/h | 63.9 | L/h | intravenous injection, IV; normal,healthy; Caucasian; Male, men; | DRUGBANK |
| Volume of Distribution | 608.0 | L | 608.0 | L | at steady state; intravenous injection, IV; | DRUGBANK | Volume of Distribution | 661.0 | L | 661.0 | L | Average volume of distribution; at steady state; | DRUGBANK | Volume of Distribution | 704.0 | L | 704.0 | L | at steady state; intravenous injection, IV; normal,healthy; Caucasian; Male, men; | DRUGBANK | Volume of Distribution | 4.2 | L/kg | 4.2 | L/kg | intravenous injection, IV; | DRUGBANK | Volume of Distribution | 557.0 | L | 557.0 | L | at steady state; intravenous injection, IV; normal,healthy; Caucasian; Male, men; | DRUGBANK |
| Half-life | 15.1 | h | 15.1 | h | inhalation, IH; | DRUGBANK | Half-life | 24.0 | h | 24 | h | intranasal; | DRUGBANK |
| Eliminate Route | 90.0 | % | ≥90 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 1.5 | % | 1-2 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 5.0 | % | <5 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1