Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD13783 ...
Drug Name Acemetacin
Molecular Weight 415.83
Molecular Formula C21H18ClNO6
CAS Number 53164-05-9
SMILES COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(=O)OCC(O)=O
External Links
DRUGBANK DB13783
PubChem Compound 1981

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.49 - 4.49 - Lead Optimization for Medicinal Chemists. Zaragoza Dorwald F. (2012). Wiley-VCH
Boiling Point 637.0 ℃ 637 ℃ 'MSDS'
Melting Point 151.5 ℃ 151.5 ℃ 'MSDS'
pKa 2.6 - 2.6 - 'MSDS'

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 597.5 ng.h/ml 483-712 ng.h/ml PO, oral; DRUGBANK
Bioavailability 66.0 % 66 % Oral multiple dose; DRUGBANK
C Max 276.8 ng/ml 276.8 ng/ml PO, oral; Elderly; DRUGBANK
C Max 187.0 ng/ml 187 ng/ml PO, oral; young; DRUGBANK
T Max 2.5 h 2.5 h PO, oral; DRUGBANK
Clearance 0.28 L/h/kg 4.59 ml/min/kg intravenous injection, IV; normal,healthy; DRUGBANK
Volume of Distribution 0.60 L/kg 0.5-0.7 L/kg Apparent volume of distribution; DRUGBANK
Half-life 4.5 h 4.5 h elimination half-life; at steady state; DRUGBANK
Eliminate Route 40.0 % 40 % Urinary excretion; DRUGBANK
Eliminate Route 60.0 % 60 % Faeces excretion; DRUGBANK
Protein Binding 90.0 % >90 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1