Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD13421 ...
Drug Name Edoxudine
Molecular Weight 256.258
Molecular Formula C11H16N2O5
CAS Number 15176-29-1
SMILES CCC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
External Links
DRUGBANK DB13421
PubChem Compound 66377

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -1.09 - -1.09 - Cheraghali M., et al. (1994). Biochemical Pharmacology.
Melting Point 153.0 ℃ 153 ℃ EPA
Water Solubility 38.4 mg/L >38.4 mcg/ml Burnham Center for Chemical Genomics.
pKa 9.98 - 9.98 - 'MSDS'

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 49.0 % 49 % intravenous injection, IV; mouse; DRUGBANK
C Max 2.4 ng/mg 2.4 mcg/g intravenous injection, IV; mouse; DRUGBANK
T Max 0.52 h 31.1 min intravenous injection, IV; mouse; DRUGBANK
Clearance 5.1 L/h 85.0 ml/min Plasma clearance; DRUGBANK
Half-life 0.0233 h 1.4 min distribution half-life; intravenous injection, IV; mouse; DRUGBANK
Half-life 0.40 h 24.1 min elimination half-life; intravenous injection, IV; mouse; different study; DRUGBANK
Protein Binding 7.0 % ~7 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1