Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| AUC | 77465.0 | ng.h/ml | 77465.0 | ng.h/ml | PO, oral; | DRUGBANK | AUC | 154930.0 | ng.h/ml | 154930.0 | ng.h/ml | PO, oral; high-fat meal; | high-fat meal ↑ ; | DRUGBANK |
| C Max | 8625.0 | ng/ml | 8625 | ng/ml | PO, oral; | DRUGBANK | C Max | 17250.0 | ng/ml | 17250 | ng/ml | PO, oral; high-fat meal; | high-fat meal ↑ ; | DRUGBANK |
| T Max | 2.5 | h | 2.5 | h | PO, oral; | DRUGBANK | T Max | 5.0 | h | 5 | h | PO, oral; high-fat meal; | high-fat meal ↑ ; | DRUGBANK |
| Tss | 168.0 | h | 7 | day | PO, oral; | DRUGBANK | |
| Clearance | 5.1 | L/h | 5.1 | L/h | apparent clearance; | DRUGBANK | |
| Volume of Distribution | 187.0 | L | 187.0 | L | Apparent volume of distribution; | DRUGBANK | |
| Half-life | 26.6 | h | ~26.6 | h | elimination half-life; | DRUGBANK | |
| Toxicity NOAEL | 10.0 | mg/kg/day | 10.0 | mg/kg/day | Rattus, Rat; | DRUGBANK | Toxicity NOAEL | 6.0 | mg/kg/day | 6.0 | mg/kg/day | dog; | DRUGBANK |
| Eliminate Route | 65.0 | % | 65 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 27.0 | % | 27 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 28.6 | % | ~28.6 | % | Faeces excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | ~99 | % | high protein binding; human, homo sapiens; | DRUGBANK | Protein Binding | 98.9 | % | ~98.9 | % | high protein binding; human, homo sapiens; | DRUGBANK | Protein Binding | 89.0 | % | ~89 | % | high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 800.0 | mg/day | 800 | mg/day | PO, oral | Turalio | pexidartinib | PDR |
| Max dose for geriatric | 800.0 | mg/day | 800 | mg/day | PO, oral | Turalio | pexidartinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1