Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12941 ...
Drug Name Darolutamide
Molecular Weight 398.85
Molecular Formula C19H19ClN6O2
CAS Number 1297538-32-9
SMILES C[C@@H](CN1C=CC(=N1)C1=CC=C(C#N)C(Cl)=C1)NC(=O)C1=NNC(=C1)C(C)O
External Links
DRUGBANK DB12941
PubChem Compound 67171867

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability 14.0 - 14.0 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828636/
Log P 1.904 - 1.904 - http://www.chemspider.com/Chemical-Structure.38772320.html
Boiling Point 719.5 ℃ 719.5±60.0 ℃ https://www.chemicalbook.com/ChemicalProductProperty_EN_CB43052901.htm
pKa 11.75 - 11.75 - https://s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB12941.pdf?1577134173

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 52.8 ng.h/ml 52.82 ng.h/ml PO, oral; DRUGBANK
Bioavailability 30.0 % 30 % PO, oral; fasting; DRUGBANK
Bioavailability 67.5 % 60-75 % PO, oral; food; DRUGBANK
Css 4790.0 ng/ml 4.79 mg/L DRUGBANK
T Max 4.0 h 3-5 h PO, oral; fasting; DRUGBANK
T Max 5.5 h 3-8 h PO, oral; food; DRUGBANK
T Max 4.5 h 3-6 h PO, oral; DRUGBANK
T Max 4.0 h 4 h PO, oral; DRUGBANK
Clearance 7.0 L/h 116.0 ml/min DRUGBANK
Volume of Distribution 119.0 L 119.0 L Apparent volume of distribution; intravenous injection, IV; DRUGBANK
Half-life 20.0 h ~20 h DRUGBANK
Half-life 20.0 h ~20 h Active metabolite; DRUGBANK
Half-life 12.5 h 10-15 h terminal half-life; different study; DRUGBANK
Eliminate Route 63.4 % 63.4 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 32.4 % 32.4 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 4.4 % 4.43 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 9.7 % 9.72 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 92.0 % 92 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1