Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12887 ...
Drug Name Tazemetostat
Molecular Weight 572.75
Molecular Formula C34H44N4O4
CAS Number 1403254-99-8
SMILES CCN(C1CCOCC1)C1=C(C)C(=CC(=C1)C1=CC=C(CN2CCOCC2)C=C1)C(=O)NCC1=C(C)C=C(C)NC1=O
External Links
DRUGBANK DB12887
PubChem Compound 66558664

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.82 - 2.82 - ChemSpider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 3340.0 ng.h/ml 3340.0 ng.h/ml DRUGBANK
Bioavailability 33.0 % 33 % DRUGBANK
C Max 829.0 ng/ml 829 ng/ml DRUGBANK
T Max 1.5 h 1-2 h DRUGBANK
Clearance 274.0 L/h 274.0 L/h Total clearance; DRUGBANK
Volume of Distribution 1230.0 L 1230.0 L DRUGBANK
Half-life 3.1 h 3.1 h elimination half-life; DRUGBANK
Eliminate Route 15.0 % 15 % Urinary excretion; DRUGBANK
Eliminate Route 79.0 % 79 % Faeces excretion; DRUGBANK
Protein Binding 88.0 % 88 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1