Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100 | % | PO, oral; | DRUGBANK |
| AUC | 1331600.0 | ng.h/ml | 1331.6 | mcg.h/ml | PO, oral; normal,healthy; Female, women; | DRUGBANK |
| C Max | 45400.0 | ng/ml | 45.4 | mcg/ml | PO, oral; normal,healthy; Female, women; | DRUGBANK |
| T Max | 4.0 | h | 4(3-4) | h | PO, oral; normal,healthy; Female, women; | DRUGBANK |
| Metabolic | 1.0 | % | <1 | % | Liver metabolism; | DRUGBANK |
| Clearance | 1.5 | L/h | ~25 | ml/min | Total clearance; | DRUGBANK | Clearance | 0.23 | L/h | ~3.9 | ml/min | Renal clearance; | DRUGBANK |
| Volume of Distribution | 45.5 | L | ~42-49 | L | Apparent volume of distribution; | DRUGBANK |
| Half-life | 17.0 | h | ~17 | h | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 300.0 | mg/kg | 300.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 3200.0 | mg/kg | 3200.0 | mg/kg | PO, oral; rabbit; | DRUGBANK | Toxicity LD50 | 980.0 | mg/kg | 980.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Toxicity MTD | 300.0 | mg/kg/day | 300.0 | mg/kg/day | Female, women; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 15.0 | % | ~15 | % | Urinary excretion; Oral single dose; Unchanged drug; | DRUGBANK |
| Protein Binding | 10.0 | % | <5-15 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1