Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.72 | - | 3.72 | - | DRUGBANK |
| Boiling Point | 618.6 | ℃ | 618.6±55.0 | ℃ | http://www.chemspider.com/Chemical-Structure.32701544.html |
| pKa | 9.41 | - | 9.41 | - | https://patents.google.com/patent/EP3310331A1/en |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 49200.0 | ng.h/ml | 49.2 | mcg.h/ml | PO, oral; | DRUGBANK |
| Bioavailability | 25.0 | % | 25 | % | Tablet, PO, oral; | DRUGBANK |
| C Max | 37100.0 | ng/ml | 37.1 | mcg/ml | PO, oral; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | intravenous injection, IV; | DRUGBANK | T Max | 1.8 | h | 1.76 | h | Tablet, PO, oral; | DRUGBANK |
| Clearance | 16.5 | L/h | 2.9-30 | L/h | Total clearance; | DRUGBANK | Clearance | 0.24 | L/h/kg | 3.96 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 86.1 | L | 86.1(34.2-153) | L | Average volume of distribution; Pneumonia, Pneu; patients; | DRUGBANK | Volume of Distribution | 1.3 | L/kg | 1.32 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.0 | h | 8 | h | elimination half-life; community-acquired bacterial pneumonia; patients; | DRUGBANK | Half-life | 13.2 | h | 13.2 | h | normal,healthy; intravenous infusion, IV in drop; | DRUGBANK | Half-life | 6.4 | h | 6.4 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 14.0 | % | ~14 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 77.3 | % | 77.3 | % | Faeces excretion; intravenous injection, IV; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 88.5 | % | 88.5 | % | Faeces excretion; PO, oral; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 15.5 | % | 15.5 | % | Urinary excretion; intravenous injection, IV; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 5.3 | % | 5.3 | % | Urinary excretion; PO, oral; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 5.1 | % | 3.24-7.03 | % | Faeces excretion; intravenous injection, IV; adults; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK | Eliminate Route | 14.4 | % | 6.9-21.95 | % | Faeces excretion; PO, oral; adults; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK | Eliminate Route | 1.8 | % | 1.49-2.18 | % | Urinary excretion; intravenous injection, IV; adults; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK |
| Protein Binding | 96.0 | % | 94.8-97.1 | % | plasma proteins; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Protein Binding | 83.5 | % | 80-87 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1