Basic Information
| Drug ID | DDPD12615 |
|
| Drug Name | Plazomicin | |
| Molecular Weight | 592.691 | |
| Molecular Formula | C25H48N6O10 | |
| CAS Number | 1154757-24-0 | |
| SMILES | CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@H]3OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC(=O)[C@@H](O)CCN)OC[C@]1(C)O | |
| External Links | ||
| DRUGBANK | DB12615 | |
| PubChem Compound | 42613186 | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 257000.0 | ng.h/ml | 257±67.0 | ug.h/ml | intravenous infusion, IV in drop; normal,healthy; adults; | DRUGBANK | AUC | 226000.0 | ng.h/ml | 226±113 | ug.h/ml | intravenous infusion, IV in drop; complicated urinary tract infections; adults; | DRUGBANK |
| C Max | 73700.0 | ng/ml | 73.7±19.7 | ug/ml | intravenous infusion, IV in drop; normal,healthy; adults; | DRUGBANK | C Max | 51000.0 | ng/ml | 51.0±26.7 | ug/ml | intravenous infusion, IV in drop; complicated urinary tract infections; adults; | DRUGBANK |
| Clearance | 4.5 | L/h | 4.5±0.9 | L/h | Average clearance; intravenous infusion, IV in drop; normal,healthy; adults; | DRUGBANK | Clearance | 5.1 | L/h | 5.1±2.01 | L/h | Average clearance; intravenous infusion, IV in drop; complicated urinary tract infections; patients; | DRUGBANK | Clearance | 0.0684 | L/h/kg | 1.14 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 17.9 | L | 17.9±4.8 | L | Average volume of distribution; normal,healthy; adults; | DRUGBANK | Volume of Distribution | 30.8 | L | 30.8±12.1 | L | Average volume of distribution; complicated urinary tract infections; patients; | DRUGBANK | Volume of Distribution | 0.22 | L/kg | 0.22 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.5 | h | 3.5±0.5 | h | normal,healthy; adults; normal renal function; intravenous infusion, IV in drop; | DRUGBANK | Half-life | 3.4 | h | 3.4 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 20.0 | % | ~20 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1