Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.73 | - | 3.73 | - | https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8709 |
| Boiling Point | 648.3 | ℃ | 648.3±65.0 | ℃ | https://www.chemsrc.com/en/cas/1306760-87-1_828967.html |
| Melting Point | 135.5 | ℃ | 134-137 | ℃ | https://www.trc-canada.com/product-detail/?CatNum=O880000&__cf_chl_jschl_tk__=47418a3658c1bed2236975a78c4d009d9726aa64-1585324169-0-AVBdS0uIBZsziaubuiosHQ9SfMRbB8tzILtS_D8ROwXY3jfZIfe7nf68lYLXjCK3VPlPXWBy25ZsDzjuSRHMsq4i6AooTGfw__9JzT3wXrvVSSMU2EcrV7Mv40mnq3e2lIo4_w_bP6jZ3VXuonZ_xdQiH-fceyd07BbLIF4BZmVUCw323soeydBwwDrMkF8dmXn9dgJ2cvO1O9LQY8_gDfhGL3Es8UF5YZpSXPUJEPZZo2_oXA4uk-2QpHpCZeR5oZIdF_CMMX2z5--DAw52pjMVLVTwvoNQS0ux0IEnKEV-UYKTAUK2pG7eAUZl2Cjvrg |
| pKa | 14.73 | - | 14.73±0.10 | - | https://www.chemicalbook.com/ChemicalProductProperty_EN_CB42716147.htm |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 4.5 | ng.h/ml | 4.46 | ng.h/ml | PO, oral; | DRUGBANK |
| C Max | 0.24 | ng/ml | 0.244 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 7.0 | h | 6-8 | h | PO, oral; | DRUGBANK |
| Tss | 102.0 | h | 102 | h | PO, oral; | DRUGBANK |
| Metabolic | 73.0 | % | 73 | % | DRUGBANK | Metabolic | 15.0 | % | 15 | % | DRUGBANK |
| Clearance | 192.0 | L/h | 192.0 | L/h | apparent clearance; PO, oral; | DRUGBANK | Clearance | 233.0 | L/h | 233.0 | L/h | PO, oral; | DRUGBANK |
| Volume of Distribution | 5590.0 | L | 5590.0 | L | Average volume of distribution; | DRUGBANK | Volume of Distribution | 87.0 | L | 73-101 | L | DRUGBANK |
| Half-life | 19.0 | h | 17-21 | h | DRUGBANK | |
| Toxicity NOAEL | 0.16 | mg/kg/day | 0.164 | mg/kg/day | monkey; | DRUGBANK | Toxicity NOAEL | 0.0530 | mg/kg/day | ~0.053 | mg/kg/day | human, homo sapiens; | DRUGBANK |
| Eliminate Route | 26.0 | % | ~26 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 37.0 | % | ~37 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 98.0 | % | >98 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1