Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12500 ...
Drug Name Fedratinib
Molecular Weight 524.678
Molecular Formula C27H36N6O3S
CAS Number 936091-26-8
SMILES CC1=CN=C(NC2=CC=C(OCCN3CCCC3)C=C2)N=C1NC1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C
External Links
DRUGBANK DB12500
PubChem Compound 16722836
PDR 24375

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Water Solubility 4.0 mg/L 4 μg/ml FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 26870.0 ng.h/ml 26870.0 ng.h/ml PO, oral; DRUGBANK
C Max 1804.0 ng/ml 1804 ng/ml PO, oral; DRUGBANK
T Max 2.4 h 1.75-3 h PO, oral; DRUGBANK
Clearance 13.0 L/h 13.0 L/h DRUGBANK
Volume of Distribution 1770.0 L 1770.0 L Apparent volume of distribution; DRUGBANK
Half-life 41.0 h 41 h DRUGBANK
Half-life 114.0 h 114 h terminal half-life; DRUGBANK
Eliminate Route 77.0 % 77 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 5.0 % 5 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 17.7 % 17.71 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 0.15 % 0.15 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 92.0 % ≥92 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 400.0 mg/day 400 mg/day PO, oral Inrebic fedratinib PDR
Max dose for geriatric 400.0 mg/day 400 mg/day PO, oral Inrebic fedratinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1