Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 463.0 | ng/ml | 463(105-1670) | ng/ml | DRUGBANK | |
| Metabolic | 90.0 | % | 90 | % | DRUGBANK | Metabolic | 10.0 | % | <10 | % | DRUGBANK |
| Clearance | 17.9 | L/h | 17.9 | L/h | Average clearance; | DRUGBANK | Clearance | 0.39 | L/h/kg | 6.42 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 871.0 | L | 871.0 | L | Average volume of distribution; | DRUGBANK | Volume of Distribution | 10.3 | L/kg | 10.34 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 39.1 | h | 39.1(14.6-82.4) | h | elimination half-life; | DRUGBANK | Half-life | 25.2 | h | 25.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 20.0 | % | ~20 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 22.0 | % | 22 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 30.0 | % | ~30 | % | Faeces excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 15.0 | % | ~15 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 84.2 | % | 84.2 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 60.0 | mg | 60 | mg | intravenous injection, IV | ALIQOPA | copanlisib | PDR |
| Max dose for geriatric | 60.0 | mg | 60 | mg | intravenous injection, IV | ALIQOPA | copanlisib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1