Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12455 ...
Drug Name Omadacycline
Molecular Weight 556.66
Molecular Formula C29H40N4O7
CAS Number 389139-89-3
SMILES [H][C@@]12CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C
External Links
DRUGBANK DB12455
PubChem Compound 54697325

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 34.5 % 34.5 % PO, oral; DRUGBANK
T Max 2.5 h 2.5 h PO, oral; DRUGBANK
Clearance 11.2 L/h 11.24 L/h Average clearance; DRUGBANK
Clearance 2.9 L/h 2.4-3.3 L/h Renal clearance; DRUGBANK
Clearance 0.14 L/h/kg 2.34 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 256.0 L 256.0 L Average volume of distribution; DRUGBANK
Volume of Distribution 190.0 L 190.0 L Steady state volume of distribution; DRUGBANK
Volume of Distribution 2.7 L/kg 2.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 16.2 h 16.2 h elimination half-life; DRUGBANK
Half-life 15.0 h 15 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 27.0 % 27 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 14.4 % 14.4 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 81.1 % 81.1 % Faeces excretion; PO, oral; DRUGBANK
Protein Binding 20.0 % 20 % Plasma Concentration → ; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1