Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12364 ...
Drug Name Betrixaban
Molecular Weight 451.91
Molecular Formula C23H22ClN5O3
CAS Number 330942-05-7
SMILES COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC1=CC=C(Cl)C=N1
External Links
DRUGBANK DB12364
PubChem Compound 10275777
PDR 24114

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 206.0 ℃ 200-212 ℃ Vincent, et al. Crystalline forms of a Factor Xa inhibitor. Patent application number WO 2012031017 A1
Water Solubility 2600.0 mg/L 2.5-2.7 mg/ml Vincent, et al. Crystalline forms of a Factor Xa inhibitor. Patent application number WO 2012031017 A1

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 34.0 % 34 % PO, oral; DRUGBANK
T Max 3.5 h 3-4 h PO, oral; normal,healthy; DRUGBANK
Metabolic 1.0 % <1 % Liver metabolism; DRUGBANK
Volume of Distribution 32.0 L/kg 32.0 L/kg Apparent volume of distribution; DRUGBANK
Half-life 23.0 h 19-27 h DRUGBANK
Eliminate Route 85.0 % 85 % Faeces excretion; DRUGBANK
Eliminate Route 11.0 % 11 % Urinary excretion; DRUGBANK
Protein Binding 60.0 % ~60 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 160.0 mg 160 mg PO, oral Bevyxxa betrixaban PDR
Max dose for geriatric 160.0 mg 160 mg PO, oral Bevyxxa betrixaban PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1