Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12329 ...
Drug Name Eravacycline
Molecular Weight 558.563
Molecular Formula C27H31FN4O8
CAS Number 1207283-85-9
SMILES [H][C@@]12CC3=C(F)C=C(NC(=O)CN4CCCC4)C(O)=C3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
External Links
DRUGBANK DB12329
PubChem Compound 54726192

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 1069.2 L/h 17.82 L/min DRUGBANK
Clearance 0.22 L/h/kg 3.71 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 321.0 L 321.0 L at steady state; DRUGBANK
Volume of Distribution 2.3 L/kg 2.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 20.0 h 20 h elimination half-life; DRUGBANK
Eliminate Route 47.0 % 47 % Faeces excretion; DRUGBANK
Eliminate Route 34.0 % ~34 % Urinary excretion; DRUGBANK
Eliminate Route 20.0 % 20 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 17.0 % 17 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 84.5 % 79-90 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1