Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 64.0 | % | 64 | % | DRUGBANK | |
| T Max | 2.0 | h | 2 | h | DRUGBANK | |
| Clearance | 6.4 | L/h | 106.0 | ml/min | PO, oral; | DRUGBANK | Clearance | 0.56 | L/h | 9.3 | ml/min | Renal clearance; | DRUGBANK |
| Volume of Distribution | 60.5 | L | 60.5 | L | Steady state volume of distribution; intravenous injection, IV; | DRUGBANK |
| Half-life | 15.0 | h | 15 | h | elimination half-life; | DRUGBANK |
| Eliminate Route | 6.0 | % | 6 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 76.0 | % | ~76 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Pifeltro | doravirine | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Pifeltro | doravirine | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Pifeltro | doravirine | PDR |
| Max dose for geriatric | 200.0 | mg/day | 200 | mg/day | PO, oral | Pifeltro | doravirine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1