Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12267 ...
Drug Name Brigatinib
Molecular Weight 584.1
Molecular Formula C29H39ClN7O2P
CAS Number 1197953-54-0
SMILES COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1
External Links
DRUGBANK DB12267
PubChem Compound 68165256
PDR 24157

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.17 - 5.17 - Molbase, MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 8165.0 ng.h/ml 8165.0 ng.h/ml DRUGBANK
AUC 20276.0 ng.h/ml 20276.0 ng.h/ml DRUGBANK
C Max 552.0 ng/ml 552 ng/ml DRUGBANK
C Max 1452.0 ng/ml 1452 ng/ml DRUGBANK
T Max 2.5 h 1-4 h PO, oral; DRUGBANK
Metabolic 72.4 % 72.4 % Liver metabolism; DRUGBANK
Metabolic 27.6 % 27.6 % Liver metabolism; DRUGBANK
Clearance 12.7 L/h 12.7 L/h apparent clearance; PO, oral; at steady state; DRUGBANK
Volume of Distribution 153.0 L 153.0 L Apparent volume of distribution; at steady state; DRUGBANK
Half-life 25.0 h 25 h at steady state; DRUGBANK
Eliminate Route 65.0 % 65 % Faeces excretion; DRUGBANK
Eliminate Route 25.0 % 25 % Urinary excretion; DRUGBANK
Protein Binding 66.0 % 66 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 180.0 mg/day 180 mg/day PO, oral qd Alunbrig brigatinib PDR
Max dose for geriatric 180.0 mg/day 180 mg/day PO, oral qd Alunbrig brigatinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1