Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.48 | - | 3.48 | - | http://helminto.inta.gob.ar/Fasciola/Alvarezetal.pdf |
| Boiling Point | 496.0 | ℃ | 496 | ℃ | http://sitem.herts.ac.uk/aeru/vsdb/Reports/1773.htm |
| Melting Point | 190.0 | ℃ | 189-191 | ℃ | https://www.trc-canada.com/product-detail/?T773825 |
| Water Solubility | 10.0 | mg/L | 1 | mg/dl | http://sitem.herts.ac.uk/aeru/vsdb/Reports/1773.htm |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 2057.2 | ng.h/ml | 5.72 | umol.h/L | Oral single dose; fascioliasis; food; | DRUGBANK | AUC | 138824.9 | ng.h/ml | 386.0 | umol.h/L | Oral single dose; fascioliasis; food; Components; | DRUGBANK | AUC | 10969.3 | ng.h/ml | 30.5 | umol.h/L | Oral single dose; fascioliasis; food; Active metabolite; | DRUGBANK |
| C Max | 1.2 | ng/ml | 1.16 | umol/L | Oral single dose; fascioliasis; food; | DRUGBANK | C Max | 38.6 | ng/ml | 38.6 | umol/L | Oral single dose; fascioliasis; food; Components; | DRUGBANK | C Max | 2.3 | ng/ml | 2.29 | umol/L | Oral single dose; fascioliasis; food; Active metabolite; | DRUGBANK |
| T Max | 3.5 | h | 3-4 | h | Oral single dose; fascioliasis; food; | DRUGBANK | T Max | 3.5 | h | 3-4 | h | Oral single dose; fascioliasis; food; Components; | DRUGBANK | T Max | 3.5 | h | 3-4 | h | Oral single dose; fascioliasis; food; Active metabolite; | DRUGBANK |
| Volume of Distribution | 1.0 | L/kg | 1.0 | L/kg | Apparent volume of distribution; food; patients; | DRUGBANK |
| Half-life | 8.0 | h | ~8 | h | DRUGBANK | Half-life | 14.0 | h | ~14 | h | Metabolite; | DRUGBANK | Half-life | 11.0 | h | ~11 | h | Metabolite; | DRUGBANK |
| Toxicity LD50 | 8000.0 | mg/kg | >8 | g/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 8000.0 | mg/kg | >8 | g/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 90.0 | % | 90 | % | Faeces excretion; animals; | DRUGBANK | Eliminate Route | 10.0 | % | <10 | % | Urinary excretion; PO, oral; animals; | DRUGBANK |
| Protein Binding | 96.7 | % | 96.7 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1