Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12243 ...
Drug Name Edaravone
Molecular Weight 174.203
Molecular Formula C10H10N2O
CAS Number 89-25-8
SMILES CC1=NN(C(=O)C1)C1=CC=CC=C1
External Links
DRUGBANK DB12243
PubChem Compound 4021
PDR 24080

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 129.7 ℃ 129.7 ℃ FDA Label
Water Solubility 1000.0 mg/L <1 mg/ml MSDS
pKa 7.0 - 7 - Watanabe T, Tahara M, Todo S: The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther. 2008 Summer;26(2):101-14. doi: 10.1111/j.1527-3466.2008.00041.x. [A19140]

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 38.0 % 38 % PO, oral; mouse; DRUGBANK
C Max 888.0 ng/ml 888 ng/ml intravenous infusion, IV in drop; normal,healthy; Male, men; adults; DRUGBANK
Clearance 6.0 L/h 0.1 L/min Plasma clearance; intravenous infusion, IV in drop; Single dose; DRUGBANK
Clearance 0.0852 L/h/kg 1.42 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 18.5 L/kg 18.5 L/kg Average volume of distribution; intravenous infusion, IV in drop; DRUGBANK
Volume of Distribution 0.23 L/kg 0.23 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.3 h 4.5-6 h elimination half-life; DRUGBANK
Half-life 2.4 h 2-2.8 h Metabolite; DRUGBANK
Half-life 2.4 h 2.36 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1915.0 mg/kg 1915.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 0.80 % ~0.7-0.9 % Unchanged drug; DRUGBANK
Protein Binding 92.0 % 92 % high protein binding; human, homo sapiens; Plasma Concentration → ; DRUGBANK
Protein Binding 90.0 % 89-91 % high protein binding; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 60.0 mg/day 60 mg/day intravenous injection, IV Radicava edaravone PDR
Max dose for geriatric 60.0 mg/day 60 mg/day intravenous injection, IV Radicava edaravone PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1