Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12161 ...
Drug Name Deutetrabenazine
Molecular Weight 323.466
Molecular Formula C19H27NO3
CAS Number 1392826-25-3
SMILES [2H]C([2H])([2H])OC1=CC2=C(C=C1OC([2H])([2H])[2H])[C@@H]1CC(=O)[C@@H](CC(C)C)CN1CC2
External Links
DRUGBANK DB12161
PubChem Compound 73442840
PDR 24069

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 47.0 L/h 47.0 L/h Average clearance; Huntington's disease; DRUGBANK
Clearance 70.0 L/h 70.0 L/h Average clearance; Huntington's disease; DRUGBANK
Volume of Distribution 500.0 L ~500 L Average volume of distribution; DRUGBANK
Volume of Distribution 730.0 L ~730 L Average volume of distribution; DRUGBANK
Half-life 9.5 h 9-10 h DRUGBANK
Eliminate Route 80.5 % ~75-86 % Urinary excretion; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 9.5 % 8-11 % Faeces excretion; normal,healthy; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 48.0 mg/day 48 mg/day PO, oral Austedo deutetrabenazine PDR
Max dose for adults 18.0 mg/dose 18 mg/dose PO, oral Austedo deutetrabenazine PDR
Max dose for adults 36.0 mg/day 36 mg/day PO, oral Austedo deutetrabenazine PDR
Max dose for geriatric 48.0 mg/day 48 mg/day PO, oral Austedo deutetrabenazine PDR
Max dose for geriatric 18.0 mg/dose 18 mg/dose PO, oral Austedo deutetrabenazine PDR
Max dose for geriatric 36.0 mg/day 36 mg/day PO, oral Austedo deutetrabenazine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1