Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12147 ...
Drug Name Erdafitinib
Molecular Weight 446.555
Molecular Formula C25H30N6O2
CAS Number 1346242-81-6
SMILES COC1=CC(=CC(OC)=C1)N(CCNC(C)C)C1=CC=C2N=CC(=NC2=C1)C1=CN(C)N=C1
External Links
DRUGBANK DB12147
PubChem Compound 67462786
PDR 24334

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Water Solubility 1000.0 mg/L <1 mg/ml MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 29268.0 ng.h/ml 29268.0 ng.h/ml DRUGBANK
C Max 1399.0 ng/ml 1399 ng/ml DRUGBANK
T Max 2.5 h 2.5 h DRUGBANK
Tss 336.0 h 2 week DRUGBANK
Clearance 0.36 L/h 0.362 L/h apparent clearance; DRUGBANK
Clearance 0.26 L/h 0.26 L/h PO, oral; DRUGBANK
Volume of Distribution 27.5 L 26-29 L Apparent volume of distribution; patients; DRUGBANK
Half-life 59.0 h 59 h effective half-life; DRUGBANK
Half-life 55.0 h 50-60 h effective half-life; DRUGBANK
Eliminate Route 69.0 % 69 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 19.0 % 19 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 13.1 % ~13.11 % Faeces excretion; Oral single dose; Unchanged drug; DRUGBANK
Eliminate Route 2.5 % 2.47 % Urinary excretion; Oral single dose; Unchanged drug; DRUGBANK
Protein Binding 99.8 % ~99.8 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 9.0 mg/day 9 mg/day PO, oral qd Balversa erdafitinib PDR
Max dose for geriatric 9.0 mg/day 9 mg/day PO, oral qd Balversa erdafitinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1