DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD12141
Drug Name	Gilteritinib
Molecular Weight	552.724
Molecular Formula	C29H44N8O3
CAS Number	1254053-43-4
SMILES	CCC1=C(NC2CCOCC2)N=C(NC2=CC=C(N3CCC(CC3)N3CCN(C)CC3)C(OC)=C2)C(=N1)C(N)=O
External Links
	DRUGBANK	DB12141
	PubChem Compound	49803313
	PDR	24275

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	99.0	-	99.0	-	'MSDS'
Boiling Point	696.0	℃	696	℃	'MSDS'
Water Solubility	1000.0	mg/L	<1	mg/ml	'MSDS'

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	6943.0	ng.h/ml	6943.0	ng.h/ml	PO, oral;		DRUGBANK
C Max	374.0	ng/ml	374	ng/ml	PO, oral;		DRUGBANK
T Max	2.0	h	2	h	PO, oral;		DRUGBANK
T Max	5.0	h	4-6	h	PO, oral; fasting;		DRUGBANK
T Max	7.0	h	6-8	h	PO, oral; high-fat meal;	high-fat meal ↑ ;	DRUGBANK
Tss	360.0	h	15	day	PO, oral;		DRUGBANK
Clearance	14.9	L/h	14.85	L/h			DRUGBANK
Volume of Distribution	1092.0	L	1092.0	L	Total volume of distribution;		DRUGBANK
Volume of Distribution	1100.0	L	1100.0	L	Total volume of distribution;		DRUGBANK
Half-life	102.0	h	~45-159	h			DRUGBANK
Eliminate Route	64.5	%	64.5	%	Faeces excretion;		DRUGBANK
Protein Binding	94.0	%	94	%	plasma proteins;		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	120.0	mg/day	120	mg/day	PO, oral	Xospata	gilteritinib	PDR
Max dose for geriatric	120.0	mg/day	120	mg/day	PO, oral	Xospata	gilteritinib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1