Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12130 ...
Drug Name Lorlatinib
Molecular Weight 406.421
Molecular Formula C21H19FN6O2
CAS Number 1454846-35-5
SMILES C[C@H]1OC2=C(N)N=CC(=C2)C2=C(C#N)N(C)N=C2CN(C)C(=O)C2=C1C=C(F)C=C2
External Links
DRUGBANK DB12130
PubChem Compound 71731823
PDR 24265

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 81.0 % 81 % PO, oral; DRUGBANK
T Max 1.2 h 1.2(0.5-4) h Oral single dose; DRUGBANK
T Max 2.0 h 2(0.53-23) h Oral multiple dose; DRUGBANK
Clearance 11.0 L/h 11.0 L/h Average clearance; Oral single dose; DRUGBANK
Clearance 18.0 L/h 18.0 L/h Average clearance; at steady state; DRUGBANK
Volume of Distribution 305.0 L 305.0 L Steady state volume of distribution; intravenous injection, IV; Single dose; DRUGBANK
Half-life 24.0 h 24 h elimination half-life; Oral single dose; DRUGBANK
Eliminate Route 48.0 % 48 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 41.0 % 41 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 0.48 % <0.48 % Urinary excretion; Oral single dose; Unchanged drug; DRUGBANK
Eliminate Route 3.7 % ~3.69 % Faeces excretion; Oral single dose; Unchanged drug; DRUGBANK
Protein Binding 66.0 % 66 % plasma proteins; high protein binding; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 100.0 mg/day 100 mg/day PO, oral qd Lorbrena lorlatinib PDR
Max dose for geriatric 100.0 mg/day 100 mg/day PO, oral qd Lorbrena lorlatinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1