Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12035 ...
Drug Name Sarecycline
Molecular Weight 487.509
Molecular Formula C24H29N3O8
CAS Number 1035654-66-0
SMILES [H][C@@]12CC3=C(CN(C)OC)C=CC(O)=C3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
External Links
DRUGBANK DB12035
PubChem Compound 54681908

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
T Max 1.8 h 1.5-2 h DRUGBANK
T Max 2.3 h 2.03-2.53 h PO, oral; high-fat meal; high-fat meal ↑ ; DRUGBANK
Metabolic 15.0 % <15 % Liver metabolism; DRUGBANK
Clearance 3.0 L/h 3.0 L/h apparent clearance; PO, oral; at steady state; DRUGBANK
Volume of Distribution 94.2 L 91.4-97.0 L Apparent volume of distribution; at steady state; DRUGBANK
Half-life 21.5 h 21-22 h elimination half-life; DRUGBANK
Eliminate Route 42.6 % 42.6 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 44.1 % 44.1 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 6.3 % 6.34 % Faeces excretion; Oral single dose; Unchanged drug; DRUGBANK
Eliminate Route 10.9 % 10.89 % Urinary excretion; Oral single dose; Unchanged drug; DRUGBANK
Protein Binding 68.6 % 62.5-74.7 % high protein binding; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1