DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD12015
Drug Name	Alpelisib
Molecular Weight	441.47
Molecular Formula	C19H22F3N5O2S
CAS Number	1217486-61-7
SMILES	CC1=C(SC(NC(=O)N2CCC[C@H]2C(N)=O)=N1)C1=CC(=NC=C1)C(C)(C)C(F)(F)F
External Links
	DRUGBANK	DB12015
	PubChem Compound	56649450

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	11100.0	ng.h/ml	11,100±3770	ng.h/ml			DRUGBANK
AUC	19203.0	ng.h/ml	19203.0	ng.h/ml	PO, oral; high-fat meal;	high-fat meal ↑ ;	DRUGBANK
AUC	19647.0	ng.h/ml	19647.0	ng.h/ml	PO, oral; low fat meal;	low fat meal ↑ ;	DRUGBANK
C Max	1320.0	ng/ml	1320±912	ng/ml			DRUGBANK
C Max	2429.0	ng/ml	2429	ng/ml	PO, oral; high-fat meal;	high-fat meal ↑ ;	DRUGBANK
C Max	2831.0	ng/ml	2831	ng/ml	PO, oral; low fat meal;	low fat meal ↑ ;	DRUGBANK
T Max	2.0	h	2	h			DRUGBANK
Clearance	39.0	L/h	39.0	L/h	apparent clearance; PO, oral;		DRUGBANK
Clearance	9.2	L/h	9.2	L/h	food;		DRUGBANK
Volume of Distribution	114.0	L	114.0	L	Apparent volume of distribution;		DRUGBANK
Half-life	8.5	h	8-9	h			DRUGBANK
Eliminate Route	81.0	%	81	%	Faeces excretion; PO, oral;		DRUGBANK
Eliminate Route	14.0	%	14	%	Urinary excretion; PO, oral;		DRUGBANK
Eliminate Route	36.0	%	36	%	Faeces excretion; PO, oral; Unchanged drug;		DRUGBANK
Eliminate Route	2.0	%	2	%	Urinary excretion; PO, oral; Unchanged drug;		DRUGBANK
Protein Binding	89.0	%	89	%			DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1