Basic Information

Drug ID DDPD12010 ...
Drug Name Fostamatinib
Molecular Weight 580.4595
Molecular Formula C23H26FN6O9P
CAS Number 901119-35-5
SMILES COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC
External Links
DRUGBANK DB12010
PubChem Compound 11671467

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 55.0 % 55 % DRUGBANK
T Max 1.5 h 1.5 h DRUGBANK
T Max 4.5 h 4.5 h PO, oral; high-fat meal; high-fat meal ↑ ; DRUGBANK
Clearance 18.0 L/h ~300 ml/min apparent clearance; PO, oral; DRUGBANK
Volume of Distribution 400.0 L 400.0 L Apparent volume of distribution; PO, oral; DRUGBANK
Half-life 15.0 h ~15 h elimination half-life; DRUGBANK
Eliminate Route 80.0 % ~80 % Faeces excretion; DRUGBANK
Protein Binding 98.3 % 98.3 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1