Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD12001 ...
Drug Name Abemaciclib
Molecular Weight 506.606
Molecular Formula C27H32F2N8
CAS Number 1231929-97-7
SMILES CCN1CCN(CC2=CC=C(NC3=NC=C(F)C(=N3)C3=CC(F)=C4N=C(C)N(C(C)C)C4=C3)N=C2)CC1
External Links
DRUGBANK DB12001
PubChem Compound 46220502
PDR 24143

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 45.0 % 45 % DRUGBANK
C Max 158.0 ng/ml 158 ng/ml Oral single dose; DRUGBANK
T Max 6.0 h 6 h Oral single dose; DRUGBANK
T Max 5.0 h 4-6 h PO, oral; DRUGBANK
Clearance 26.0 L/h 26.0 L/h Average clearance; patients; DRUGBANK
Volume of Distribution 690.3 L 690.3 L Average volume of distribution; DRUGBANK
Half-life 18.3 h 18.3 h elimination half-life; patients; DRUGBANK
Eliminate Route 81.0 % 81 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 3.0 % 3 % Urinary excretion; Oral single dose; DRUGBANK
Protein Binding 96.5 % 95-98 % animals; high protein binding; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 200.0 mg/day 200 mg/day PO, oral bid Verzenio abemaciclib PDR
Max dose for adults 150.0 mg/day 150 mg/day PO, oral bid Verzenio abemaciclib PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral bid Verzenio abemaciclib PDR
Max dose for geriatric 150.0 mg/day 150 mg/day PO, oral bid Verzenio abemaciclib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1