Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11995 ...
Drug Name Avatrombopag
Molecular Weight 649.65
Molecular Formula C29H34Cl2N6O3S2
CAS Number 570406-98-3
SMILES OC(=O)C1CCN(CC1)C1=C(Cl)C=C(C=N1)C(=O)NC1=NC(C2=CC(Cl)=CS2)=C(S1)N1CCN(CC1)C1CCCCC1
External Links
DRUGBANK DB11995
PubChem Compound 9852519

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 4198.0 ng.h/ml 4198.0 ng.h/ml normal,healthy; DRUGBANK
C Max 166.0 ng/ml 166 ng/ml normal,healthy; DRUGBANK
T Max 6.5 h 5-8 h PO, oral; Caucasian; Asian; DRUGBANK
Clearance 6.9 L/h 6.9 L/h Average clearance; DRUGBANK
Volume of Distribution 180.0 L 180.0 L Average volume of distribution; DRUGBANK
Half-life 19.0 h ~19 h elimination half-life; DRUGBANK
Eliminate Route 88.0 % 88 % Faeces excretion; DRUGBANK
Eliminate Route 6.0 % 6 % Urinary excretion; DRUGBANK
Eliminate Route 29.9 % 29.92 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 96.0 % >96 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1