Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11986 ...
Drug Name Entrectinib
Molecular Weight 560.65
Molecular Formula C31H34F2N6O2
CAS Number 1108743-60-7
SMILES CN1CCN(CC1)C1=CC=C(C(=O)NC2=NNC3=CC=C(CC4=CC(F)=CC(F)=C4)C=C23)C(NC2CCOCC2)=C1
External Links
DRUGBANK DB11986
PubChem Compound 25141092
PDR 24379

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
T Max 4.5 h 4-5 h Oral single dose; DRUGBANK
Metabolic 76.0 % 76 % DRUGBANK
Clearance 19.6 L/h 19.6 L/h apparent clearance; DRUGBANK
Clearance 52.4 L/h 52.4 L/h apparent clearance; DRUGBANK
Volume of Distribution 551.0 L 551.0 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 81.1 L 81.1 L Apparent volume of distribution; DRUGBANK
Half-life 20.0 h 20 h elimination half-life; DRUGBANK
Half-life 40.0 h 40 h Active metabolite; DRUGBANK
Eliminate Route 83.0 % 83 % Faeces excretion; Single dose; DRUGBANK
Eliminate Route 3.0 % 3 % Urinary excretion; Single dose; DRUGBANK
Protein Binding 99.0 % >99 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for children 600.0 mg/day 600 mg/day PO, oral Rozlytrek entrectinib PDR
Max dose for children 500.0 mg/day 500 mg/day PO, oral Rozlytrek entrectinib PDR
Max dose for children 400.0 mg/day 400 mg/day PO, oral Rozlytrek entrectinib PDR
Max dose for adolescents 600.0 mg/day 600 mg/day PO, oral Rozlytrek entrectinib PDR
Max dose for adolescents 500.0 mg/day 500 mg/day PO, oral Rozlytrek entrectinib PDR
Max dose for adolescents 400.0 mg/day 400 mg/day PO, oral Rozlytrek entrectinib PDR
Max dose for adults 600.0 mg/day 600 mg/day PO, oral qd Rozlytrek entrectinib PDR
Max dose for geriatric 600.0 mg/day 600 mg/day PO, oral qd Rozlytrek entrectinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1