Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11978 ...
Drug Name Glasdegib
Molecular Weight 374.448
Molecular Formula C21H22N6O
CAS Number 1095173-27-5
SMILES CN1CC[C@H](C[C@@H]1C1=NC2=CC=CC=C2N1)NC(=O)NC1=CC=C(C=C1)C#N
External Links
DRUGBANK DB11978
PubChem Compound 25166913
PDR 24269

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability 5.98e-06 - 5.98e-06 - Munchhof M., et al. (2011). ACS Med Chem Lett.
Log P 2.28 - 2.28 - Munchhof M., et al. (2011). ACS Med Chem Lett.
Boiling Point 214.0 ℃ 214 ℃ 'MSDS'
Melting Point 214.0 ℃ >214 ℃ 'MSDS'
Water Solubility 20.0 mg/L 0.02 mg/ml Munchhof M., et al. 2011). ACS Med Chem Lett.
pKa 6.0 - 6 - Munchhof M., et al. (2011). ACS Med Chem Lett.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 9587.0 ng.h/ml 9587.0 ng.h/ml DRUGBANK
AUC 9310.0 ng.h/ml 9310.0 ng.h/ml Oral multiple dose; DRUGBANK
Bioavailability 55.0 % 55 % PO, oral; DRUGBANK
C Max 321.0 ng/ml 321 ng/ml DRUGBANK
C Max 542.0 ng/ml 542 ng/ml Oral multiple dose; DRUGBANK
Css 388.0 ng/ml 388.0 ng/ml Oral multiple dose; DRUGBANK
T Max 4.0 h 4 h DRUGBANK
T Max 4.0 h 4 h Oral multiple dose; DRUGBANK
Clearance 5.2 L/h 5.22 L/h DRUGBANK
Volume of Distribution 225.0 L 225.0 L DRUGBANK
Half-life 17.4 h 17.4 h DRUGBANK
Toxicity LD50 3000.0 mg/kg 3000.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 49.0 % 49 % Urinary excretion; DRUGBANK
Eliminate Route 42.0 % 42 % Faeces excretion; DRUGBANK
Eliminate Route 8.3 % 8.3 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 8.4 % 8.4 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 91.0 % 91 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 100.0 mg/day 100 mg/day PO, oral Daurismo glasdegib PDR
Max dose for geriatric 100.0 mg/day 100 mg/day PO, oral Daurismo glasdegib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1