Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | 5.98e-06 | - | 5.98e-06 | - | Munchhof M., et al. (2011). ACS Med Chem Lett. |
| Log P | 2.28 | - | 2.28 | - | Munchhof M., et al. (2011). ACS Med Chem Lett. |
| Boiling Point | 214.0 | ℃ | 214 | ℃ | 'MSDS' |
| Melting Point | 214.0 | ℃ | >214 | ℃ | 'MSDS' |
| Water Solubility | 20.0 | mg/L | 0.02 | mg/ml | Munchhof M., et al. 2011). ACS Med Chem Lett. |
| pKa | 6.0 | - | 6 | - | Munchhof M., et al. (2011). ACS Med Chem Lett. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 9587.0 | ng.h/ml | 9587.0 | ng.h/ml | DRUGBANK | |
| AUC | 9310.0 | ng.h/ml | 9310.0 | ng.h/ml | Oral multiple dose; | DRUGBANK |
| Bioavailability | 55.0 | % | 55 | % | PO, oral; | DRUGBANK |
| C Max | 321.0 | ng/ml | 321 | ng/ml | DRUGBANK | |
| C Max | 542.0 | ng/ml | 542 | ng/ml | Oral multiple dose; | DRUGBANK |
| Css | 388.0 | ng/ml | 388.0 | ng/ml | Oral multiple dose; | DRUGBANK |
| T Max | 4.0 | h | 4 | h | DRUGBANK | |
| T Max | 4.0 | h | 4 | h | Oral multiple dose; | DRUGBANK |
| Clearance | 5.2 | L/h | 5.22 | L/h | DRUGBANK | |
| Volume of Distribution | 225.0 | L | 225.0 | L | DRUGBANK | |
| Half-life | 17.4 | h | 17.4 | h | DRUGBANK | |
| Toxicity LD50 | 3000.0 | mg/kg | 3000.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 49.0 | % | 49 | % | Urinary excretion; | DRUGBANK |
| Eliminate Route | 42.0 | % | 42 | % | Faeces excretion; | DRUGBANK |
| Eliminate Route | 8.3 | % | 8.3 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Eliminate Route | 8.4 | % | 8.4 | % | Faeces excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 91.0 | % | 91 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Daurismo | glasdegib | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Daurismo | glasdegib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1