Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 50.0 | % | >50 | % | PO, oral; | DRUGBANK |
| T Max | 1.6 | h | 1.6 | h | PO, oral; | DRUGBANK |
| Clearance | 20.2 | L/h | 20.2 | L/h | DRUGBANK | |
| Volume of Distribution | 92.0 | L | 92.0 | L | Apparent volume of distribution; | DRUGBANK |
| Half-life | 3.5 | h | 3.5 | h | terminal half-life; | DRUGBANK |
| Eliminate Route | 62.0 | % | 62 | % | Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 31.0 | % | 31 | % | Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 19.8 | % | 19.84 | % | Faeces excretion; Oral single dose; human, homo sapiens; Unchanged drug; | DRUGBANK | Eliminate Route | 2.0 | % | 2.01 | % | Urinary excretion; Oral single dose; human, homo sapiens; Unchanged drug; | DRUGBANK |
| Protein Binding | 97.0 | % | 97 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 90.0 | mg/day | 90 | mg/day | PO, oral | Mektovi | binimetinib | PDR |
| Max dose for geriatric | 90.0 | mg/day | 90 | mg/day | PO, oral | Mektovi | binimetinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1