DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD11963
Drug Name	Dacomitinib
Molecular Weight	469.939
Molecular Formula	C24H25ClFN5O2
CAS Number	1110813-31-4
SMILES	COC1=C(NC(=O)\C=C\CN2CCCCC2)C=C2C(NC3=CC(Cl)=C(F)C=C3)=NC=NC2=C1
External Links
	DRUGBANK	DB11963
	PubChem Compound	11511120
	PDR	24248

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	3.92	-	3.92	-	'MSDS'
Boiling Point	665.7	℃	665.7	℃	'MSDS'
Melting Point	185.5	℃	184-187	℃	Williams J., et al. (2014). Canc. Treatment Rev. 40, 917.
Water Solubility	1000.0	mg/L	<1	mg/ml	'MSDS'

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
AUC	2213.0	ng.h/ml	2213.0	ng.h/ml	PO, oral;	DRUGBANK
Bioavailability	80.0	%	80	%	PO, oral;	DRUGBANK
C Max	104.0	ng/ml	104	ng/ml	PO, oral;	DRUGBANK
T Max	6.0	h	6	h	PO, oral;	DRUGBANK
Clearance	27.6	L/h	27.6	L/h	apparent clearance;	DRUGBANK
Volume of Distribution	2415.0	L	2415.0	L		DRUGBANK
Half-life	70.0	h	70	h		DRUGBANK
Eliminate Route	79.0	%	79	%	Faeces excretion;	DRUGBANK
Eliminate Route	3.0	%	3	%	Urinary excretion;	DRUGBANK
Protein Binding	98.0	%	98	%		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Frequency	Brand Name	Component	Reference
Max dose for adults	45.0	mg	45	mg	PO, oral	qd	Vizimpro	dacomitinib	PDR
Max dose for geriatric	45.0	mg	45	mg	PO, oral	qd	Vizimpro	dacomitinib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1