Basic Information

Drug ID DDPD11952 ...
Drug Name Duvelisib
Molecular Weight 416.87
Molecular Formula C22H17ClN6O
CAS Number 1201438-56-3
SMILES C[C@H](NC1=C2N=CNC2=NC=N1)C1=CC2=CC=CC(Cl)=C2C(=O)N1C1=CC=CC=C1
External Links
DRUGBANK DB11952
PubChem Compound 50905713

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.55 - 4.55 - 'MSDS'
Melting Point 190.0 >190 'MSDS'
Water Solubility 1000.0 mg/L <1 mg/ml 'MSDS'

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 10530.0 ng.h/ml 2001-19059 ng.h/ml DRUGBANK
Bioavailability 42.0 % 42 % DRUGBANK
C Max 1882.5 ng/ml 471-3294 ng/ml DRUGBANK
T Max 1.5 h 1-2 h DRUGBANK
Clearance 7.4 L/h 3.6-11.2 L/h DRUGBANK
Volume of Distribution 64.0 L 26-102 L DRUGBANK
Half-life 8.1 h 5.2-10.9 h DRUGBANK
Eliminate Route 79.0 % 79 % Faeces excretion; DRUGBANK
Eliminate Route 14.0 % 14 % Urinary excretion; DRUGBANK
Eliminate Route 10.0 % ~10 % Unchanged drug; DRUGBANK
Protein Binding 98.0 % >98 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1