DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD11943
Drug Name	Delafloxacin
Molecular Weight	440.76
Molecular Formula	C18H12ClF3N4O4
CAS Number	189279-58-1
SMILES	NC1=NC(N2C=C(C(O)=O)C(=O)C3=CC(F)=C(N4CC(O)C4)C(Cl)=C23)=C(F)C=C1F
External Links
	DRUGBANK	DB11943
	PubChem Compound	487101
	PDR	24113

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Bioavailability	58.8	%	58.8	%	PO, oral;	DRUGBANK
T Max	0.75	h	0.75(0.5-4)	h	Oral single dose;	DRUGBANK
T Max	1.0	h	1(1-1.2)	h	intravenous injection, IV;	DRUGBANK
Tss	1.0	h	1(0.5-6)	h	Oral single dose;	DRUGBANK
Tss	1.0	h	1	h	intravenous injection, IV;	DRUGBANK
Clearance	16.3	L/h	16.3	L/h	Average clearance;	DRUGBANK
Clearance	0.14	L/h/kg	2.33	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	39.0	L	30-48	L	Steady state volume of distribution;	DRUGBANK
Volume of Distribution	0.35	L/kg	0.35	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	3.7	h	3.7	h	elimination half-life;	DRUGBANK
Half-life	6.4	h	4.2-8.5	h	elimination half-life; Oral multiple dose;	DRUGBANK
Half-life	2.1	h	2.1	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Eliminate Route	28.0	%	28	%	Faeces excretion; Unchanged drug;	DRUGBANK
Protein Binding	84.0	%	84	%	plasma proteins; human, homo sapiens;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	900.0	mg/day	900	mg/day	PO, oral	Baxdela	delafloxacin	PDR
Max dose for adults	600.0	mg/day	600	mg/day	intravenous injection, IV	Baxdela	delafloxacin	PDR
Max dose for geriatric	900.0	mg/day	900	mg/day	PO, oral	Baxdela	delafloxacin	PDR
Max dose for geriatric	600.0	mg/day	600	mg/day	intravenous injection, IV	Baxdela	delafloxacin	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1