Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11915 ...
Drug Name Valbenazine
Molecular Weight 418.578
Molecular Formula C24H38N2O4
CAS Number 1025504-45-3
SMILES COC1=C(OC)C=C2[C@H]3C[C@@H](OC(=O)[C@@H](N)C(C)C)[C@H](CC(C)C)CN3CCC2=C1
External Links
DRUGBANK DB11915
PubChem Compound 24795069
PDR 24071

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 49.0 % 49 % PO, oral; DRUGBANK
T Max 0.75 h 0.5-1 h PO, oral; DRUGBANK
Clearance 7.2 L/h 7.2 L/h DRUGBANK
Clearance 0.10 L/h/kg 1.71 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 92.0 L 92.0 L DRUGBANK
Volume of Distribution 1.3 L/kg 1.31 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 18.5 h 15-22 h DRUGBANK
Half-life 18.5 h 15-22 h Active metabolite; DRUGBANK
Half-life 18.0 h 18 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 60.0 % ~60 % Urinary excretion; DRUGBANK
Eliminate Route 30.0 % ~30 % Faeces excretion; DRUGBANK
Protein Binding 99.0 % >99 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 80.0 mg/day 80 mg/day PO, oral Ingrezza valbenazine PDR
Max dose for geriatric 80.0 mg/day 80 mg/day PO, oral Ingrezza valbenazine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1