DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD11901
Drug Name	Apalutamide
Molecular Weight	477.44
Molecular Formula	C21H15F4N5O2S
CAS Number	956104-40-8
SMILES	CNC(=O)C1=CC=C(C=C1F)N1C(=S)N(C(=O)C11CCC1)C1=CC(=C(N=C1)C#N)C(F)(F)F
External Links
	DRUGBANK	DB11901
	PubChem Compound	24872560
	PDR	24195

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	100000.0	ng.h/ml	100.0	mcg.h/ml	PO, oral;		DRUGBANK
AUC	124000.0	ng.h/ml	124.0	mcg.h/ml	Active metabolite;		DRUGBANK
Bioavailability	100.0	%	~100	%	PO, oral;		DRUGBANK
C Max	6000.0	ng/ml	6.0	mcg/ml	PO, oral;		DRUGBANK
C Max	5900.0	ng/ml	5.9	mcg/ml	Active metabolite;		DRUGBANK
T Max	2.0	h	2(1-5)	h	PO, oral;		DRUGBANK
Tss	672.0	h	4	week	PO, oral;		DRUGBANK
Clearance	1.3	L/h	1.3	L/h	apparent clearance; Single dose;	extended release formulation ↑ ;	DRUGBANK
Clearance	2.0	L/h	2.0	L/h	apparent clearance; Multiple dose; at steady state;		DRUGBANK
Volume of Distribution	276.0	L	~276	L	Apparent volume of distribution; at steady state;		DRUGBANK
Half-life	72.0	h	~3	day	effective half-life; NM-CRPC; patients; at steady state;		DRUGBANK
Eliminate Route	65.0	%	65	%	Urinary excretion; Oral single dose;		DRUGBANK
Eliminate Route	24.0	%	24	%	Faeces excretion; Oral single dose;		DRUGBANK
Eliminate Route	0.78	%	0.78	%	Urinary excretion; Oral single dose; Unchanged drug;		DRUGBANK
Eliminate Route	0.36	%	0.36	%	Faeces excretion; Oral single dose; Unchanged drug;		DRUGBANK
Protein Binding	96.0	%	96	%			DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	240.0	mg/day	240	mg/day	PO, oral	Erleada	apalutamide	PDR
Max dose for geriatric	240.0	mg/day	240	mg/day	PO, oral	Erleada	apalutamide	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1