Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11855 ...
Drug Name Revefenacin
Molecular Weight 597.76
Molecular Formula C35H43N5O4
CAS Number 864750-70-9
SMILES CN(CCN1CCC(CC1)OC(=O)NC1=CC=CC=C1C1=CC=CC=C1)C(=O)C1=CC=C(CN2CCC(CC2)C(N)=O)C=C1
External Links
DRUGBANK DB11855
PubChem Compound 11753673
PDR 24264

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.22 - 3.22 - 'MSDS'
Boiling Point 777.5 ℃ 777.5 ℃ 'MSDS'
Water Solubility 1000.0 mg/L <1 mg/ml 'MSDS'

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 0.20 ng.h/ml 0.03-0.36 ng.h/ml DRUGBANK
C Max 0.0850 ng/ml 0.02-0.15 ng/ml DRUGBANK
T Max 0.50 h 0.48-0.51 h DRUGBANK
Tss 168.0 h 7 day DRUGBANK
Volume of Distribution 218.0 L 218.0 L intravenous injection, IV; DRUGBANK
Half-life 46.2 h 22.3-70 h terminal half-life; DRUGBANK
Eliminate Route 54.0 % 54 % Faeces excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 27.0 % 27 % Urinary excretion; intravenous injection, IV; DRUGBANK
Protein Binding 71.0 % 71 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 0.175 mg/day 175 mcg/day inhalation, IH Yupelri revefenacin PDR
Max dose for geriatric 0.175 mg/day 175 mcg/day inhalation, IH Yupelri revefenacin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1