DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD11828
Drug Name	Neratinib
Molecular Weight	557.05
Molecular Formula	C30H29ClN6O3
CAS Number	698387-09-6
SMILES	CCOC1=C(NC(=O)\C=C\CN(C)C)C=C2C(NC3=CC=C(OCC4=CC=CC=N4)C(Cl)=C3)=C(C=NC2=C1)C#N
External Links
	DRUGBANK	DB11828
	PubChem Compound	9915743
	PDR	24127

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
T Max	5.0	h	2-8	h		DRUGBANK
Metabolic	15.0	%	15	%	Active metabolite;	DRUGBANK
Metabolic	33.0	%	33	%	Derivative;	DRUGBANK
Metabolic	22.0	%	22	%	Components;	DRUGBANK
Metabolic	4.0	%	4	%	Drug form;	DRUGBANK
Clearance	216.0	L/h	216.0	L/h	Total clearance; Multiple dose;	DRUGBANK
Clearance	281.0	L/h	281.0	L/h	Total clearance; at steady state;	DRUGBANK
Volume of Distribution	6433.0	L	6433.0	L	Apparent volume of distribution;	DRUGBANK
Half-life	12.0	h	7-17	h	Single dose;	DRUGBANK
Half-life	14.6	h	14.6	h	elimination half-life; Multiple dose;	DRUGBANK
Half-life	21.6	h	21.6	h		DRUGBANK
Half-life	13.8	h	13.8	h		DRUGBANK
Half-life	10.4	h	10.4	h		DRUGBANK
Eliminate Route	97.1	%	97.1	%	Faeces excretion;	DRUGBANK
Eliminate Route	1.1	%	1.13	%	Urinary excretion;	DRUGBANK
Protein Binding	99.0	%	>99	%	plasma proteins; human, homo sapiens;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	240.0	mg/day	240	mg/day	PO, oral	Nerlynx	neratinib	PDR
Max dose for geriatric	240.0	mg/day	240	mg/day	PO, oral	Nerlynx	neratinib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1