Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11817 ...
Drug Name Baricitinib
Molecular Weight 371.42
Molecular Formula C16H17N7O2S
CAS Number 1187594-09-7
SMILES CCS(=O)(=O)N1CC(CC#N)(C1)N1C=C(C=N1)C1=C2C=CNC2=NC=N1
External Links
DRUGBANK DB11817
PubChem Compound 44205240
PDR 24210

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Boiling Point 707.2 ℃ 707.2 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 79.0 % 79 % PO, oral; DRUGBANK
T Max 1.0 h 1(0.5-3) h PO, oral; DRUGBANK
T Max 0.50 h 0.5 h PO, oral; food; food ↓ ; DRUGBANK
Metabolic 10.0 % <10 % DRUGBANK
Clearance 9.4 L/h ~9.42 L/h apparent clearance; rheumatoid arthritis; patients; DRUGBANK
Volume of Distribution 76.0 L 76.0 L Average volume of distribution; intravenous infusion, IV in drop; DRUGBANK
Half-life 12.5 h ~12.5 h rheumatoid arthritis; patients; DRUGBANK
Protein Binding 50.0 % ~50 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 2.0 mg/day 2 mg/day PO, oral Olumiant baricitinib PDR
Max dose for geriatric 2.0 mg/day 2 mg/day PO, oral Olumiant baricitinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1